Study:Reporting of Adverse Events in Published and Unpublished Studies of Health Care Interventions


RESEARCH ARTICLE


Reporting of Adverse Events in Published and Unpublished Studies of Health Care

Interventions: A Systematic Review

Su Golder1*, Yoon K. Loke2, Kath Wright3, Gill Norman4

1Department of Health Sciences, University of York, York, United Kingdom,2Norwich Medical School,

University of East Anglia, Norwich, United Kingdom,3Centre for Reviews and Dissemination (CRD),

University of York, York, United Kingdom,4School of Nursing, Midwifery & Social Work, University of

Manchester, Manchester, United Kingdom


Conclusions

There is strong evidence that much of the information on adverse events remains unpub-

lished and that the number and range of adverse events is higher in unpublished than in

published versions of the same study. The inclusion of unpublished data can also reduce

the imprecision of pooled effect estimates during meta-analysis of adverse events.



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